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Chemically, metformin resembles naturally occurring biguanide molecules in the French lilac, a plant used in traditional medicine for hundreds of years (Witters 2001)
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Fifth, optimize everything else
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The antidiabetic drug metformin , amino acid derivative carnosine, and B-vitamin derivatives benfotiamine and pyridoxal-5-phosphate are examples of agents that mitigate glycation- and AGE-related tissue damage (Ceriello 2009
Another 2025 survey published in JAMA Health Forum noted that, should Medicare pay for the drugs, it could avoid spending a hypothetical $18.2 billion on obesity-related health expenditures over 10 years while dishing out $65.9 billion annually on the GLP-1s by year 10, thereby negating any savings
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